July 13-15, 2016

Tokyo Bay Maihama Hotel Club Resort
1-7, Maihama, Urayasu-shi, Chiba 279-0031, Japan
TEL: +81-47-355-2411
http://www.tbm-clubresort.jp/eng/

　　　　　　　　　　　　　　　　　　　　 April 29, 2016
Abstract Submission Deadline: April 15, 2016
*We have extended the deadline
for abstract submission.

Registration Deadline: June 17, 2016

Organizing Committee:

JCA　　 Dr.Takuro Nakamura (The Cancer Institute of JFCR)
　　　　 　Dr.Issay Kitabayashi (National Cancer Center)
　　　　 　Dr.Shigeru Chiba (University of Tsukuba)

AACR　 Dr.Jonathan D. Licht (University of Florida Health Cancer Center)
　　　　 　Dr.Ross L. Levine (Memorial Sloan Kettering Cancer Center)
　　　　 　Dr.Catriona Jamieson (Moores UC San Diego Cancer Center)

Program (tentative)

July 13

Time	Session	Chairperson	Speaker	Title
18:00-18:10	Welcome Address
18:10-19:30	Keynote	Dr.Licht Dr.Nakamura	Dr. Jonathan D. Licht (The University of Florida)	Disordered Histone Methylation in Lymphoid Malignancy
			Dr.Takuro Nakamura (The Cancer Institute of JFCR)	Signaling and Transcriptional Networks in Myeloid Leukemogenesis
20:00-22:00	Welcome Party

July 14

Time	Session	Chairperson	Speaker	Title
8:00-9:30	1. Aging and epigenetics in hematopoietic malignancies	Dr.Figueora Dr.Chiba	Dr.Atsushi Iwama (Chiba University)	Deregulated Polycomb-group Gene Functions in Hematological Malignancies
			Dr.Maria E. (Ken) Figueroa (University of Michigan)	Epigenetic Deregulation in the Aging Hematopoietic Stem Cell
			Dr. Shigeru Chiba(University of Tsukuba)	Aging and TET Dioxygenases in Leukemo/lymphomagenesis
9:30-9:50	Break
9:50-11:20	2. Myeloproliferative neoplasms and myelodysplastic syndrome	Dr.Levine Dr.Kitamura	Dr.Ross L. Levine (Memorial Sloan Kettering Cancer Center)	Role of JAK-STAT Pathway Activation in MPN Pathogenesis and Therapeutic Response
			Dr.Toshio Kitamura (The University of Tokyo)	The ASXL1 Mutation and the EZH2 Mutation Induced Myelodysplastic Syndromes in Mice via Distinct Mechanisms
			Dr.Hitoshi Takizawa (Kumamoto University)	Inflammation-induced Malignant Transformation of Hematopoietic Stem Cell
11:20-12:20	Lunch and Poster View
12:20-13:50	Poster Presentation
13:50-15:20	3. Recent advances in lymphoma therapeutics	Dr.Melnick Dr.Tobinai	Dr.Ari Melnick (Weill Cornell Medicine)	Epigenetic Circuits and Their Perturbation in Lymphoid Neoplasms
			Dr.Kensei Tobinai (National Cancer Center Hospital)	New Agent Development for Lymphoid Malignancies in Japan
			Dr.Yasuhito Terui (Cancer Institute Hospital of JFCR)	Recent Advances in Therapeutics for B-cell Lymphoma
15:20-15:40	Break
15:40-17:40	4. Leukemogenesis: Leukemia stem cell, metabolism and novel targets	Dr.Jamieson Dr.Kitabayashi	Dr.Atsushi Hirao (Kanazawa University)	Molecular Mechanism Linking Stem Cell Aging and Tumorigenesis in Hematopoiesis
			Dr. Catriona H. M. Jamieson (University of California, San Diego)	Malignant RNA Editing Activation Drives Cancer Stem Cell Self-renewal by Impairing Let-7 Biogenesis
			Dr.Koicji Akashi (Kyushu University)	TIM-3 and Its Ligand, Galectin-9, Constitute an Autocrine Loop Universally Critical for Development of Human Myeloid Leukemia Stem Cells
			Dr.Issay Kitabayashi (National Cancer Center Research Institute)	Novel Leukemia Stem Cell-targeted Therapy for Acute Myeloid Leukemia Based on Dual Inhibition of EZH1/EZH2
18:00-19:00	Meet the Expert (all participants)
19:30-21:30	Banquet

July 15

Time	Session	Chairperson	Speaker	Title
8:30-10:00	5. Genetic and epigenetic alterations in childhood leukemia	Dr.Ferrando Dr.Ito	Dr.Junko Takita (The Univeristy of Tokyo)	Integrated Genetic Analysis of Pediatric T-cell Acute Lymphoblastic Leukemia
			Dr.Adolfo A. Ferrando (Columbia University)	Oncogenic Signaling Pathways and Mechanisms of Resistance in Acute Lymphoblastic Leukemia
			Dr.Etsuro Ito (Hirosaki University)	Genetic and Epigenetic Alterations in Acute Megakaryoblastic Leukemia in Down Syndrome
10:00-10:20	Break
10:20-11:50	6. Genomic landscapes of lymphoid malignancies	Dr.Landau Dr.Mano	Dr.Seishi Ogawa (Kyoto University)	A Novel Genetic Mechanism of Evading Anti-tumor Immunity in Multiple Human Cancers
			Dr.Dan A. Landau (Weill Cornell Medicine)	Genetic and Epigenetic Determinant of Chronic Lymphocytic Leukemia Evolution
			Dr.Hiroyuki Mano (The University of Tokyo)	Discovery of DUX4-IGH Fusion-Type Oncogene in B-Cell Acute Lymphoblastic Leukemia of AYA Generation
11:50-12:50	Lunch and Poster View
12:50-14:20	7. Immunotherapy of hematopoietic neoplasms	Dr.Riddell Dr.Kawakami	Dr.Yutaka Kawakami (Keio University)	Current Progress and Future Perspectives in Cancer Immunotherapy: Development of Personalized Combination Immunotherapy
			Dr.Hiroyoshi Nishikawa (National Cancer Center)	Critical Role of Regulatory T Cells in Cancer Immunotherapy for Hematologic Malignancies
			Dr.Stanley R. Riddell(Fred Hutchinson Cancer Research Center)	Engineering Safe and Effective T Cell Therapy for Cancer
14:20-14:40	Break
14:40-15:40	8. Molecular biology and targets of multiple myeloma	Dr.Tiedemann Dr.Furukawa	Dr.Rodger E. Tiedemann (University of Toronto)	Intra-Tumor Heterogeneity in Multiple Myeloma and It's Role in Therapeutic Resistance and Relapse
			Dr.Yusuke Furukawa (Jichi Medical University)	Epigenetic Mechanisms of Drug Resistance in Multiple Myeloma
15:40-15:50	Closing Remarks